PROBLEM TO BE SOLVED: To provide a formulation which inhibits hyaluronidase, and is useful for the treatment of skin wrinkles and sagging as well as contact dermatitis, psoriasis, pemphigus vulgaris and the like.SOLUTION: The inventors have found out that extracts of Atractylodis rhizoma, Ishige, a mulberry looper, and Manchurian wild rice serve the purpose of this invention.COPYRIGHT: (C)2015,JPO&INPIT【課題】本発明の目的は、ヒアルロニダーゼを阻害し、シワやタルミに、さらには接触性皮膚炎、乾癬、尋常性天疱症等に有効な製剤を得ることにある。【解決手段】本発明者らが鋭意検討した結果、白朮、イシゲ、桑枝、マコモの抽出物が上記目的を達することがわかった。【選択図】なし
