Van To Tsai;Helen Kim Cho;Siradanahalli Chandrasekharalah Guru;Brian Gregory Pierce
发明人:
Helen Kim Cho,Siradanahalli Chandrasekharalah Guru,Van To Tsai,Brian Gregory Pierce
申请号：
US13701814
公开号：
US08895017B2
申请日:
2011.05.23
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention provides (a) isolated immunogenic HER-2 peptides capable of inducing immune responses against human HER-2 receptor； (b) isolated nucleic acid molecules encoding an isolated immunogenic HER-2 peptide； (c) plasmid constructs comprising a nucleic acid molecule encoding an isolated immunogenic HER-2 peptide； (d) vaccine compositions comprising an isolated immunogenic HER-2 peptide (e) vaccine compositions comprising an isolated nucleic acid molecule encoding an isolated immunogenic HER-2 peptide； and (f) methods of treating or preventing cancer, inhibiting abnormal cell proliferation, or eliciting an immune response against HER-2 protein in a mammal using (1) an isolated immunogenic HER-2 peptide, (2) nucleic acid molecule encoding an isolated immunogenic HER-2 peptide, or (3) a composition comprising an isolated immunogenic HER-2 peptide, or composition comprising a nucleic acid molecule encoding an isolated immunogenic HER-2 peptide.
