Various approaches for operating an ultrasound transducer having multiple transducer elements include acquiring one or more measurements of anatomical regions through which ultrasound waves emitted from the transducer elements travel； for each of the anatomical regions, determining values of characteristics based at least in part on the measurement(s)； computationally predicting aberrations of the ultrasound waves traveling through the anatomical regions by using the first values as input to a predictor that has been computationally trained to predict ultrasound aberrations based on values of the characteristics； and driving the transducer elements to compensate for the predicted aberrations.
