KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
发明人:
Mi Sun WON,Hyun Seung BAN,Bo Kyung KIM,Soon Woo NAM,Kyeong LEE,Young-Ju LEE,Hong-Sub LEE,Dong Uk KIM,Ki Cheol PARK,Joo-Young IM,Kyoung-Jin OH
申请号：
US15087563
公开号：
US20160235821A1
申请日:
2016.03.31
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention relates to a pharmaceutical composition for treating cancer, containing cytochrome b5 reductase 3 (CYB5R3) protein as an active ingredient. Over-expression of CYB5R3 in cancer cells results in significant reduction of hypoxia-inducible factor-1α (HIF-1α) expression, which leads inhibition of cancer cells growth in vitro and in vivo. Thus, the CYB5R3 gene or protein of the present invention can be useful as an active ingredient of a pharmaceutical composition for treating cancer.
