AMER F. SALEH,ANDREY ALEXANDROVICH ARZUMANOV,CORINNE BETTS,MATTHEW J. A WOOD,MICHAEL JOHN GAIT,TAEYOUNG KOO
申请号：
BR112014004902
公开号：
BR112014004902A2
申请日:
2012.08.29
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
The present invention discloses cell penetrating peptides (CPP or membrane translocating peptide) and their conjugates with cargo molecules. The peptides are useful as drug delivery systems, particularly as delivery vehicles for nucleotide-based therapeutics, such as polynucleotides, oligonucleotides and peptide nucleic acids. A CPPs of the invention provides a balance between good cell entry efficiency and low toxicity and comprises three contiguous domains: the central one being hydrophobic and the flanking ones consisting of arginine and aminohexanoic acid or beta-alanine residues. The hydrophobic domain contains a sequence selected from YQFLI, YRFLI, IQFLI and IRFLI.
