Methods, kits and devices to reduce dosage of a subject a hypersensitivity response to a Nucleic Acid Molecule (e.g., RNA) Made in Lipids.Claim 1: a method for reducing a response related to the infusion (IRR) and / or a hypersensitivity reaction in a subject, to a composition comprising a Lipid Formulation and a Nucleic Acid Molecule, wherein Said method comprises administering to a subject: A First dose of the composition； a Second dose of the composition； and where there is one, two,Three, Four, or all of the following conditions (a) - (e): (a) the amount of such composition administered in this first dose is not more than 1 / X, where X is 2, 3, 4, 5, 6, 7, 8, 9, 10, 15, 20, 30, 40 or 50, the amount of the Administered Dose in the second composition； (b) the can Amount of the Administered Dose in the first composition is no more than 1 / X, where X is 2, 3,4, 5, 6, 7, 8, 9, 10, 15, 20, 30, 40 or 50, the total amount of the Administered composition； (c) the first dose is given over a period of time which is not greater than 1 / X, where X is 2, 3, 4 5, 6, 7, 8, 9 or 10, the time period over which the second dose is given ； (d) the frequency of Administration, for example, in mg / ml / min or min,The First dose is not greater than 1 / X, where X is 2, 3, 4, 5, 6, 7, 8, 9, 10, 15, 20, 30, 40 or 50, the frequency of Administration of the second dose； or (e) dosages and periods of Administration the first and second dose are selected in such a way that it has And IRR and / or a hypersensitivity reaction substance in said subject.Métodos, conjuntos de elementos y dispositivos de dosificación de un sujeto para reducir una respuesta de hipersensibilidad a una molécula de ácido nucleico (por ejemplo, ARN) formulada en lípidos. Reivindicación 1: Un método para reducir una respuesta relacionada con la infusión (IRR) y/o una reacción de hipersensibilidad, en un sujeto, a una composición que comprende una formulación de lípidos y una molécula de ácido nucleico, donde
