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液體口腔用組合物之製造方法及液體口腔用組合物
专利权人:
KAO CORPORATION
发明人:
MIZUMOTO, TAKESHI,水本健
申请号:
TW104143896
公开号:
TWI667040B
申请日:
2015.12.25
申请国别(地区):
TW
年份:
2019
代理人:
摘要:
The present invention relates to a method for producing a liquid composition for oral cavity in which ²-glycyrrhetinic acid is stably dispersed or dissolved to exhibit an increased transparency and which also can ensure a sufficient amount of ²-glycyrrhetinic acid adsorbed on gingiva, even if the amount of a cationic surfactant or an anionic surfactant is restricted; and such a liquid composition for oral cavity. Specifically, the present invention relates to a method for producing a liquid composition for oral cavity, comprising the following step 1 to step 4: (Step 1) a step of blending water (F) with an organic acid and a salt thereof (E) to adjust the pH of a resultant mixture to 5 or more and 6.8 or less, (Step 2) a step of blending 0.02% by mass or more and 0.1% by mass or less of cetylpyridinium chloride (B) into the mixture, (Step 3) a step of blending 0.02% by mass or more and 0.1% by mass or less of ²-glycyrrhetinic acid (A) and 2% by mass or more and 10% by mass or less of propylene glycol (C) into the mixture, and (Step 4) a step of blending 0.45% by mass or more and 1.1% by mass or less of polyoxyethylene hydrogenated castor oil (D) into the mixture, wherein the component (A) and the component (B) are blended at a specific mass ratio, and these steps are carried out in a specific order.本發明係關於一種即便限制陽離子界面活性劑或陰離子界面活性劑之調配量,亦能夠使β-甘草次酸穩定地分散或溶解而提高透明性,且亦充分確保β-甘草次酸於牙齦之吸附量的液體口腔用組合物之製造方法及液體口腔用組合物。即,本發明係一種液體口腔用組合物之製造方法,其包括以下之步驟1~步驟4:(步驟1)調配水(F)與有機酸及其鹽(E)而將pH值調整為5以上且6.8以下之步驟、(步驟2)調配0.02質量%以上且0.1質量%以下之西吡氯銨(B)之步驟、(步驟3)調配0.02質量%以上且0.1質量%以下之β-甘草次酸(A)、及2質量%以上且10質量%以下之丙二醇(C)之步驟、以及(步驟4)調配0.45質量%以上且1.1質量%以下之聚氧乙烯氫化蓖麻油(D)之步驟;成分(A)與成分(B)為特定質量比,且以特定順序進行該等步驟。
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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