Disclosed is an electronic drop administration device and method of operation thereof. The device comprises a microcontroller communicatively coupled to at least an accelerometer or other sensors for administering one or more drops of a liquid or non-liquid substance to eyes or other body parts. The device detects whether it is in a suitable orientation and/or position before administering drops. Additionally, the device may track said administrations, detect blink events to determine whether drop administrations were successful, and distinguish between right and left eyes during or after administration. Also, event data and other useful information relating to proper patient care may be communicated to a remote device for use by a physician or other healthcare provider.