To provide the mold for extrusion molding the medical application tube and the extrusion molding method thereof in which the medical application tube having a complex profile can be molded by using a soft thermoplastic resin. The mold for extrusion molding the medical application tube (10) made of the soft thermoplastic resin provided with the flow paths (13a,13b) and (13d) sandwiching the axial portion therein comprises the mold body (21) and the pin (22) including the land portion (23). The cylindrical rear side mold space for passing the molding material between the inner peripheral surface of the recesses (26a and 27a) of the mold body (21) and the outer peripheral surface of the pin (22), and the tip end side mold space including the cross section for forming the medical application tube (10) between the inner peripheral surface of the recess (28a) and the land portion (23) of the mold body (21). Further, the cross section of the rear side portion in the cross section of the tip end side mold space is formed to the intermediate profile of the cross section of the tip end portion of the tip end side mold space and the cross section of the tip end portion of the rear side mold space.