This application describes a method and device for safely, effectively, perfusing distal to occluded arteries, based on diagnostic information from the catheter-perfusion-system based on sensors, effectors, controllers and algorithms included, with particular attention to the specific characteristics of the tissue and the fluid. Key actionable physiological values for the tissue can be calculated and derived. They include the auto-regulatory curve, with Upper and Lower limits of Auto regulation, vascular reserve, and collateral flow reserve and as auto-regulation exhaustion.
