Beth Israel Deaconess Medical Center, Inc;Massachusetts Institute of Technology
发明人:
Olivier Kocher,Monty Krieger
申请号：
US16295737
公开号：
US20190289835A1
申请日:
2019.03.07
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention relates to animal models that expresses SR-BIΔ；CT knockin. The present invention further includes animal models that express SR-BIΔ；CT and also have reduced expression or activity of ApoE and/or LDLR, wherein the latter can be accomplished by use of a compound or genetic manipulation of the gene. The present invention relates to mouse models crossed with SR-BIΔ；CT knockin mice. Specifically, the present invention relates to SR-BIΔ；CT knockin mice crossed with apolipoprotein E (ApoE) knockout mice (SR-BIΔ；CT/apoE KO), a hypoE mouse (also referred to as ApoeR61h/h which expresses an impaired ApoE protein (SR-BIΔ；CT/ApoeR61h/h)), or a LDLR knockout mouse (SR-BIΔ；CT/LDLR KO). Screening methods and compounds using these mouse models are also encompassed.
