A bioelectronic system includes a first stimulating electrode, a second stimulating electrode and a stimulating signal generator. The first stimulating electrode is configured to be coupled to a biological tissue. The second stimulating electrode is configured to be coupled to the biological tissue. The stimulating signal generator includes a fixed voltage source configured to generated a fixed voltage to the second stimulating electrode and a stimulating voltage source configured to generate a stimulating voltage to the first stimulating electrode, wherein the stimulating voltage swings up and down relative to the fixed voltage, and an amplitude of the stimulating voltage relative to the fixed voltage is fixed.生物電子系統包含一第一刺激電極,一第二刺激電極以及一刺激訊號產生器。該第一刺激電極用以耦接至一生物組織。該第二刺激電極用以耦接至該生物組織。該刺激訊號產生器包含一固定電壓源,用以產生一固定電壓至該第二刺激電極;以及一刺激電壓源,用以產生一刺激電壓至該第一刺激電極,其中該刺激電壓相對該固定電壓上下擺盪,且該刺激電壓相對該固定電壓的振幅固定。20‧‧‧生物組織110‧‧‧刺激訊號產生器120‧‧‧固定電壓源130‧‧‧刺激電壓源132‧‧‧數位控制器134‧‧‧數位對類比產生器AMP101‧‧‧運算放大器G‧‧‧接地位準S1‧‧‧第一刺激電極S2‧‧‧第二刺激電極Vs‧‧‧刺激電壓Vg‧‧‧固定電壓