THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人:
TSAI, JONATHAN,FERNHOFF, NATHANIEL,SINHA, RAHUL,RINKEVICH, YUVAL,WEISSMAN, IRVING L.
申请号：
CA3019841
公开号：
CA3019841A1
申请日:
2017.05.01
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
Aspects of the present disclosure include methods of treating a subject to reduce adhesion formation, the method comprising administering to a subject in need of thereof an agent that that targets adhesion-formation by injured mesothelial cells. The agent can act at a variety of checkpoints in the development of adhesions by injured mesothelial cells, including: targeting the injured mesothelial cells for destruction, recruiting inflammatory macrophages to the site of adhesion, preventing neutrophil recruitment to the site of adhesion, and/or inhibiting the expression or activity of a gene product whose expression is induced in the injured mesothelial cells. Compositions and kits for performing the methods are also provided.
