AGGER, ELSE, MARIE,ANDERSEN, CLAIRE,ANDERSEN, PETER,BERSRA, GURDYAL,MINIKIN, DAVID
申请号：
HRP20120722
公开号：
HRP20120722T1
申请日:
2012.09.10
申请国别(地区):
HR
年份:
2012
代理人:
摘要：
Here we identify MMG and its alpha- and ketomycolic acid derivatives as highly bioactive lipids derived from M. bovis BCG (Copenhagen) capable of stimulating and activating human DC's at exceedingly low doses. In addition to their direct role as immunostimulators of human DC's we demonstrate their use in the development of a new generation of adjuvants suitable for human administration. We furthermore identify a number of highly active synthetic MMG analogues with great potential in cancer treatment, and for vaccine adjuvants against both infectious disease and disorders like Alzheimers disease.
