Monocyclic or bicyclic ring boronic acid or ester compounds having an arylalkyl amine substituent at the 4 position and a substituted 5:6 bicyclic group at the 2 position of the mono or bicyclic ring boronic acid or ester as well as optional aliphatic, functional and/or aromatic components substituted at other positions of the mono or bicyclic boronic acid or ester compounds are disclosed. These compounds are inhibitors of the AAA proteasome complex containing p97 and are effective medicinal agents for treatment of diseases associated with p97 bioactivity such as cancer.本發明揭示單環或雙環酸或酯化合物，其具有在該單或雙環酸或酯之4位的芳基烷基胺取代基及2位的經取代之5：6雙環基團以及在該單或雙環酸或酯化合物之其他位置取代的視情況脂族、官能及/或芳族組分。此等化合物為含有p97之AAA蛋白酶體複合體的抑制劑，且為治療與p97生物活性相關之疾病(諸如癌症)的有效藥劑。
