AARON R. KUNZER,XILU WANG,ZHI TAO,MILAN FU - BRUNKO,MICHAEL D. WENDT,XIAOHONG SONG,ROBIN FREY,GEORGE DOHERTY,LE WANG,GERARD M. SULLIVAN,ANDREW JUDD,ANDREW SOUERS,TODD M. HANSEN
申请号：
ARP120103812
公开号：
AR088328A1
申请日:
2012.10.12
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
1. Compounds that inhibit the activity of Bcl-xL anti apoontology protein, compounds containing this compound, and disease treatment methods that display Bcl-xL anti apoontology protein. Characteristic requirement 1: a compound characterized by formula (1) or salt acceptable in the formula, or salt acceptable in the formula, wherein X is heteromorphic； in the compound, X is heteromorphic, and can be selectively replaced by 1, 2, 3 or 4r830808；Y1 is phenyl, or c83325235 is heterosexual；optionally fused with one or two rings selected from the group consisting of C₃₋₈ cycloalkane,C₃₋₈ cycloalkene,benzene, Care heteroarene,3. Heterosexual c83223；and C₃₋₈ heterocycloalkene；Y1 can be replaced by 1, 2, 3 or 4 replacement personnel independently selected from r83099 group；Or83099,SR8309；S (O) RSO₂R⁵,C (O) RCO (O) ROC (O) ROC (O) ORNH.8322；NHR83099,N (R)NHC (O) RNR C (O) RNHS (O) RNR S (O) RNHC (O) ORNo. 8309； C (o) or8309；NHC (O) NHNHC (O) NHRNHC (O) N (R)No. 8309； C (o) nhr8309；NR C (O) N (R)C (O) NHC (O) NHRC (O) N (R)C (O) NHOH C (O) NHORC (O) NHSO RC (O) NR SO RSO₂NH₂,SO₂NHR⁵,SO N (R)CO (O) H C (O) H OH CN NNo.8322；f. CL, Br and I； L1 were selected from the following groups: cr8310；； r8311q (cr8310；), r8311； - O - (cr8310； - r8311r) 691；(CR R) -C (O) - (CR R)(CR R) -S- (CR R)(CR R) -S (O) - (CR R)(CR R) -NR AC (O) - (CR R)(CR R) -C (O) NR A- (CR R)(CR R) -NR A- (CR R)(cr8310； - r8311) - 8347； - S (o) 83222； - 8310 a - (cr8310；； r8311) 691；y (CR R) -NR AS (O) - (CR R)and Y² is selected from the group consisting of C₃₋₁₁ alkyl,branched chain, C₃₋₇ cycloalkyl,C₄₋₇ cycloalkenyl,phenyl, and C₃₋₇ heterocyclyl；In c83323-83318327a,C₄₋₇ cycloalkenyl,phenyl, and C₃₋₇ heterocyclyl are optionally fused with one or two rings selected from the group consisting of C₃₋₈ cycloalkane,C₃₋₈ cycloalkene,benzene, Care heteroarene,3. Heterosexual c83223；and C₃₋₈ heterocycloalkene；2. For Y2, it can be replaced by 1, 2, 3, 4 or 5 replacement members independently selected from r831222 group；Or8
