The invention discloses a composition comprising at least one long chain polyunsaturated fatty acid at least one probiotic and a mixture of oligosaccharides said mixture containing at least one N acetylated oligosaccharide at least one sialylated oligosaccharide and at least one neutral oligosaccharide for use in brain growth and/or cognitive and/or psychomotor development. This composition is particularly adapted for use in infants notably preterm infants.