In an embodiment, an orally disintegrating tablet composition is provided. The orally disintegrating tablet composition includes a mannitol having a weight ratio of 40-85% in the orally disintegrating tablet composition, an active substance and a disintegrant, wherein the mannitol has a specific surface area of 1.5-4.5m2/g and the disintegrant has a weight ratio of 10-32% in the orally disintegrating tablet composition.本發明之一實施例,提供一種口崩片組成物,包括:一甘露醇,其於該口崩片組成物中之重量百分比介於40~85%;一活性物質;以及一崩散劑,其中該甘露醇之比表面積介於1.5~4.5m2/g,以及該崩散劑於該口崩片組成物中之重量百分比介於10~32%。
