Ronald Vogels,Menzo Jans Emco Havenga,David Adrianus Theodorus Maria Zuijdgeest
申请号：
US12804179
公开号：
US08114637B2
申请日:
2010.07.14
申请国别(地区):
US
年份:
2012
代理人:
摘要：
In the absence of substantial sequence overlap between a recombinant adenoviral vector and the genome of a packaging cell, helper-dependent E1-containing particles (HDEP) can be formed at low frequency. Provided are means and methods for reducing or preventing the generation of HDEP. To this purpose, novel packaging cells and methods of making these are provided.
