John Knopf;Ravindra Kumar;Robert S. Pearsall;Asya Grinberg;Jasbir Seehra
发明人:
Asya Grinberg,John Knopf,Robert S. Pearsall,Ravindra Kumar,Jasbir Seehra
申请号：
US11982738
公开号：
US08455428B2
申请日:
2007.11.02
申请国别(地区):
US
年份:
2013
代理人:
摘要：
In certain aspects, the present disclosure relates to the insight that a polypeptide comprising a ligand-binding portion of the extracellular domain of activin-like kinase I (ALK1) polypeptide may be used to inhibit angiogenesis in vivo, particularly in mammals suffering angiogenesis-related disorders. The disclosure also identifies ligands for ALK1 and demonstrates that such ligands have pro-angiogenic activity, and antibodies that inhibit receptor-ligand interaction.
