The manufacturing method and the biological surgical patches Disclosed, no immune reaction, and have good biocompatibility, there is applicability to be safe / reliable. The steps of providing animal tissue of nature with (1) a substrate, the method comprising the steps of fixed and crosslinking said substrate (1), [MEANS FOR SOLVING PROBLEMS] biological surgical patches, minimize the antigen from said substrate (1) and is manufactured by a method comprising the steps of: in the steps of tanning the said substrate (1), and a step of incorporating an active layer (2) on said substrate (1). [Selection] Figure Figure 1【課題】本発明の生体外科用パッチおよび作製方法は、免疫反応がなく、良好な生体適合性を有し、かつ、安全/信頼できる適用性がある。【解決手段】生体外科用パッチは、基質(1)を有する天然の動物組織を提供するステップと、該基質(1)を架橋かつ固定するステップと、該基質(1)に由来の抗原を最小にするステップと、該基質(1)をなめすステップと、該基質(1)中に活性層(2)を組み込むステップとを含む方法によって作製される。【選択図】図1
