PROBLEM TO BE SOLVED: To provide &Dgr;-THC prodrugs, methods of making &Dgr;-THC prodrugs, formulations comprising &Dgr;-THC prodrugs and methods of using &Dgr;-THC.SOLUTION: This invention provides a compound of formula (I) where Ris a biodegradable linker.【課題】Δ9-THCプロドラッグ、Δ9-THCプロドラッグの製造方法、Δ9-THCプロドラッグを含む製剤、及びΔ9-THCの使用方法の提供。【解決手段】式(I)の化合物[式中、R1は、生物分解性リンカーである]。【選択図】なし