TRETYAKOV ALEXANDER,FUERST DAN,SHETH KAMLESH A,RYBCZYNSKI PHILIP J
申请号：
IN201748021387
公开号：
IN201748021387A
申请日:
2017.06.19
申请国别(地区):
IN
年份:
2017
代理人:
摘要：
The present invention relates to a method for preparing isofagomine, its derivatives, or acid salts thereof, comprising: protecting the anomeric hydroxyl group of D-(-)-arabinose with a protecting group to form a glycoside further protecting by converting said protected glycoside to an acetonide using a ketal or ketone converting said acetonide to an alkoxide and reacting with an alkylating agent to form an ether converting said ether to a diol having two protecting groups further protecting said diol using selective etherification to form a triprotected arabinose derivative converting said arabinose derivative to a triprotected xylose derivative using an activated system converting said xylose derivative to a triprotected nitrile using an activated system converting said nitrile using catalytic hydrogenation.
