The invention relates to new therapeutic approaches for treating cancer, inparticular hepatocellular carcinoma, with Nanoparticles loaded with achemotherapeuticantitumoral agent. In particular, it relates to the treatment of cancer byadministration ofsaid Nanoparticles by intravenous infusion for at least 2 hours in order topreventtoxicological side effects and increase the benefit/risk ratio of thetreatment.