Ned D. Heindel;Marion Gordon;Carl Jeffrey Lacey;Abhilash N. Pillai;Jeffrey D. Laskin;Diane E. Heck
发明人:
Jeffrey D. Laskin,Ned D. Heindel,Carl Jeffrey Lacey,Abhilash N. Pillai,Marion Gordon,Diane E. Heck
申请号：
US13422565
公开号：
US20120252891A1
申请日:
2012.03.16
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Three unique subtypes of N-hydroxyamides and N-hydroxycarbamates containing both the vanilloid moiety (4-hydroxy-3-methoxybenzyl) and a lipophilic aliphatic moiety. Also disclosed are direct syntheses of these vanilloid fatty hydroxamates. The compounds possess inhibitory activity against the enzymes fatty acid amide hydrolase (FAAH) and matrix metallo-proteinase 9 (MMP-9). In addition, these substances bind to the calcium channel protein TRPV1 and inhibit vesicant-induced inflammation in skin and cornea. The compounds have utility in treating topical or systemic inflammatory processes in the skin and/or eye.
