БРИНКМАНН Ульрих (DE),ЖОРЖ Ги (DE),ХОФФМАНН Айке (DE)
申请号：
RU2015102068
公开号：
RU2015102068A
申请日:
2013.07.04
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. An antibody to theophylline, comprising: (a) the hypervariable region HVR-H3 of heavy chain comprising the amino acid sequence of SEQ ID NO: 03, (b) the hypervariable region HVR-L3 of the light chain comprising the amino acid sequence of SEQ ID NO: 07 and ( a) HVR-H2, having the amino acid sequence of SEQ ID NO: 02.2. The antibody of claim 1, comprising: (a) HVR-H1, comprising the amino acid sequence of SEQ ID NO:. 01 (b) HVR-H2, having the amino acid sequence of SEQ ID NO: 02, and (c) HVR-H3, comprising the amino acid sequence SEQ ID NO: 03.3. An antibody according to any one of claims. 1 and 2, comprising: (a) HVR-L1, containing the amino acid sequence of SEQ ID NO: 05, (b) HVR-L2, comprising the amino acid sequence of SEQ ID NO: 06, and (c) HVR-L3, comprising the amino acid sequence of SEQ ID NO: 07.4. An antibody according to claim. 1, characterized in that it is a humanized antibody and comprises a variable domain position 71 of the heavy chain according to Kabat numbering, amino acid residue arginin.5. An antibody according to claim. 1, characterized in that it is a humanized antibody and comprises at position 46 of the variable domain of the light chain according to Kabat numbering, amino acid residue leytsin.6. . The antibody of claim 1, comprising: (a) the sequence of the variable domain VH heavy chain which is identical by at least 95% amino acid sequence of SEQ ID NO: 04 (b) a light chain variable domain VL, identical by at least 95% the amino acid sequence of SEQ ID NO: 08 or (c) the sequence of VH as in (a) and the sequence of VL as in (b) wherein the amino acid residue at position 71 of the variable domain of the heavy chain according to the numbering of Kabat is an arginine, and an amino acid residue at position 46 the light chain variable domain , according to1. Антитело к теофиллину, содержащее: (а) гипервариабельный участок тяжелой цепи HVR-H3, содержащий аминокислотную последовательность SEQ ID NO: 03, (б) гипервариабельный участок легкой цепи
