The invention features a gastrointestinal anchoring system for securing a gastrointestinal device within the gastrointestinal tract of a patient. Further provided are methods of using the anchoring system to secure a gastrointestinal device within the gastrointestinal tract of a patient and methods of treatment using the anchoring system of the invention to secure a gastrointestinal device of the invention to a luminal wall within a patient's gastrointestinal tract.