PROBLEM TO BE SOLVED: To provide methods that can more easily accommodate a substance into a molecular capsule and release a substance from a molecular capsule.SOLUTION: A pH responsive molecular capsule has an amphipathic molecule represented by formula (1) as a constitutional unit, has an interior space in which a plurality of amphipathic molecules gather, and is capable of accommodating a hydrophobic compound in the interior space. [a ring α is a substituted/unsubstituted monocyclic aromatic compound, and rings β1 and β2 are substituted/unsubstituted monocyclic or polycyclic aromatic compounds the rings β1 and β2 are at positions where one atom exists between the rings, and each face inclines to the face of the ring α R is a hydrophilic group and n is an integer from 1 to X (X=the ring number of α-3).]SELECTED DRAWING: Figure 1COPYRIGHT: (C)2017,JPO&INPIT【課題】分子カプセルへの物質の収容と放出をより簡単に実施することができる方法の提供。【解決手段】式(1)で表される両親媒性分子を構成単位とし、複数の両親媒性分子が集合してなる内部空間を有し、内部空間に疎水性化合物を収容可能なpH応答性分子カプセル。[環αは置換/非置換の単環式の芳香族化合物、環β1,β2は置換/非置換の単環式又は多環式の芳香族化合物。環β1,β2は互いが1つ原子を開けた位置にあり、各面が環αの面に対して傾く。Rは親水性基、nは1からX乞の整数(X=環αの環員数-3)]【選択図】図1