Predicting tumor response to anti-ERBB3 antibodies

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专利权人:

发明人:

Sylvie Vincent,Kristan Meetze,Bin Feng,Steven Tyler,Steve Bottega,Richard Nicoletti,Donna McIntosh,Jeno Gyuris

申请号：

US14349916

公开号：

US09828635B2

申请日:

2012.10.05

申请国别(地区):

US

年份:

2017

代理人:

摘要：

A diagnostic method for predicting quantitatively whether a human tumor will be sensitive or resistant to treatment with an ERBB3 inhibitor, e.g, an anti-ERBB3 antibody, is disclosed. The method is based on measurement of NRG1 expression at the RNA level, or at the protein level, in a tissue sample from the tumor.

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