A system for determining insulin sensitivity (IS) comprising at least one processor configured for: receiving a first parameter corresponding to an insulin dose in a subcutaneous tissue； applying a first kinetic model to obtain a plasma insulin concentration based on the first parameter； receiving a second parameter corresponding to a plasma glucose concentration； determining the insulin sensitivity (IS) based on the plasma insulin concentration and the second parameter； wherein the at least one processor is further configured for providing a recommendation to a user to validate the determined insulin sensitivity value (IS).
