Protein resistant ef4g proteins, genes encoding these proteins, and cells containing these proteins or genes may all contribute to the diagnosis, treatment, or prevention of FMD. Claim 7: a method for determining the resistance to FMD, characterized by the analysis of a cell, embryo or animal to determine whether it contains a modified eIF4G gene and / or a modified eIF4G protein. Claim 8: a method for establishing a genetically modified organism characterized by transforming a native eIF4G gene into a cell,1. A basic cell or an in vitro embryo, donating a basic cell or implanting an embryo into a parent's animal. In this animal, changes in the eIF4G gene may contribute to the expression of a modified eIF4G protein variant, which is resistant to the protein activity of a protein enzyme specific to the FMD virus； O (b) introduce a foreign ef4g gene, which helps to express the corresponding protein in a primary cell or tube embryo, and clone the primary cell or implant the embryo into the parent animal,The change of eIF4G gene may help to express the modified eIF4G protein variant, which is specific to FMDV, or (c) bind (a) and (b). Claim 11: an animal characterized in that it can be obtained in some way according to any requirements 7 to 10.Proteínas eIF4G resistentes a las proteasas, genes que las codifican y células que comprenden dichas proteínas o dichos genes, todos los cuales pueden ser útiles para diagnosticar, tratar o prevenir la fiebre aftosa. Reivindicación 7: Un método para determinar la presencia de resistencia a la fiebre aftosa, caracterizado porque comprende analizar una célula, un embrión o un animal para comprobar si comprende un gen eIF4G modificado y/o una proteína de eIF4G modificada. Reivindicación 8: Un método para crear un organismo modificado genéticamente, caracterizado porque comprende (a) alterar un gen eIF4G nativo en una célula, una célula primaria o un embrión in vitro y donar la célula primaria o implantar el embrión en un animal proge
