The molecule binding to ant\u00ecgeno modified, polinucleot\u00ecdeo isolated encoding a polipept\u00ecdeo, vector, method of production of this molecule, pharmaceutical composition containing it, and use of the same
The molecule binding to antigeno modified, polinucleotideo isolated encoding a polipeptideo, vector, method of production of this molecule, pharmaceutical composition containing it, and use of the same. The present invention relates to molecules binding to the antigen modified (ABMS).In the special method, the present invention relates to recombinant monoclonal antibodies or fragments, including chimeric antibodies, humanized or primatizados or fragments, with capacity changed from mediate the activity of cell signaling through a target antigen and \/ or Capacity change mediate the cross-linking of one or more target antigens.In addition, the present invention relates to nucleic acid molecules that encode such ABMS modified and vectors and host cells comprising such nucleic acid molecules. The invention also relates to methods for the production of ABMS modified of the invention and methods of use of these ABMS modified in the treatment of diseases.In addition, the present invention relates to ABMS modified with modified glycosylation having improved therapeutic properties, including antibodies with increased fc receptor binding and function efetuadora increased.
