The present invention relates to anti-human PD-1 agonist antibodies, and uses thereof for treating autoimmune disorders such as rheumatoid arthritis or for decreasing rejection of transplanted cells and/or tissues.本發明係關於抗人類PD-1促效劑抗體及其用於治療諸如類風濕性關節炎之自體免疫病症或用於減少移植細胞及/或組織之排斥反應的用途。