Fluid delivery systems (10) capable of introducing first (12) and second (14) fluids into the first and second lumens of a multi-lumen catheter are provided. The first and second fluids are generally a dissolution fluid and a dissolution fluid attenuating fluid. Also provided are fluid delivery and kits that include the subject systems. The subject fluid delivery systems find use in a variety of different applications, and are particularly suited for use in the chemical ablation of internal vascular lesions.