Disclosed herein is a pre-filled infusion syringe for sequential intraarticular administration comprising a syringe barrel (10) having an outlet end (13) with a dispensing orifice (12), a syringe barrel A syringe plunger 16 including a cap 14, a plunger rod mounted inside the syringe barrel 10 and a plunger stopper, and a bypass stopper 18 mounted inside the syringe barrel 10, And a bypass stopper 18 for separating the first chamber 20a from the second chamber 20b located downstream and upstream of the pass stopper 18, respectively. The first chamber 20a is filled with the first composition while the second chamber 20b is filled with the second composition. (12) during the first administration phase until the bypass stopper (18) abuts the outlet end of the syringe barrel (10) when the syringe plunger is displaced along a predetermined first distance The bypass stopper 18 is slidably received within the syringe barrel 10 such that the bypass stopper is configured to move toward the outlet end of the syringe barrel to evacuate the first composition from the first chamber 20a Respectively. At this time, the bypass stopper 18 is moved during the second administration step until the plunger stopper 22 comes into contact with the bypass stopper 18 when the syringe plunger 16 is displaced along the predetermined second distance, The syringe plunger stopper 22 is moved to the bypass stopper (not shown) in order to evacuate the second composition from the second chamber 20b via the bypass stopper 18 and through the distribution orifice 12. [ 18). The first composition contained in the first chamber 20a is an aqueous composition comprising a local anesthetic agent and the second composition contained in the second chamber 20b is hyaluronic acid having a molecular weight of 0.5 to 5.0 million Daltons or 0.1% To 0.9% weight / volume of pharmaceutically acceptable salt of hyaluronic acid.본 명세서에서 순차 관절 내 투여를 위한 사전 충전식 주입 주사기가 개시되는데, 이 주사기는 분배 오리피스(12)를 구비한 출구 단부(13)를 갖는 주
