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ARTIFICIAL NUCLEIC ACID MOLECULES
专利权人:
CUREVAC AG
发明人:
GRUND, Stefanie,SCHLAKE, Thomas
申请号:
SG11201704681Q
公开号:
SG11201704681QA
申请日:
2015.12.29
申请国别(地区):
SG
年份:
2017
代理人:
摘要:
The invention relates to an artificial nucleic acid molecule comprising at least one open reading frame and at least one 3'-untranslated region element (3'-UTR element) and/or at least one 5'-untranslated region element (5'-UTR element), wherein the at least one 3'-UTR element and/or the at least one 5'-UTR element prolongs and/or increases protein production from said artificial nucleic acid molecule and wherein the at least one 3'-UTR element and/or the at least one 5'-UTR element is derived from a stable mRNA. The invention further relates to the use of such an artificial nucleic acid molecule in gene therapy and/or genetic vaccination. Furthermore, methods for identifying a 3'-UTR element and/or a 5'-UTR derived from a stable mRNA element are disclosed.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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