A DRY POWDER INHALATION SYSTEM SUITABLE FOR TRANSPULMONARY ADMINISTRATION. THE DRY POWDER INHALATION SYSTEM IS CHARACTERIZED BY USING A COMBINATION OF: (1) A VESSEL (1) HOUSING A FREEZE-DRIED COMPOSITION (2) PREPARED BY FREEZE-DRYING A COMPOSITION LIQUID CONTAINING INGREDIENTS IN A NON-DISSOLVED FORM, AND HAS: (i) A NON-POWDER CAKE-LIKE FORM, (ii) A DISINTEGRATION INDEX OF 0.05 OR MORE, AND (iii) A PROPERTY OF BECOMING FINE PARTICLES HAVING A MEAN PARTICLE DIAMETER (MASS MEDIAN AERODYNAMIC DIAMETER) OF 10 MICRONS OR LESS OR A FINE PARTICLE FRACTION OF 10% OR MORE UPON RECEIPT OF AN AIR IMPACT HAVING AN AIR SPEED OF AT LEAST 1 M/SEC AND AN AIR FLOW RATE OF AT LEAST 17 ML/SEC AND (2) A DEVICE COMPRISING A MEMBER CAPABLE OF APPLYING THE AIR IMPACT TO THE FREEZE-DRIED COMPOSITION IN SAID VESSEL (1), AND A MEMBER FOR DISCHARGING THE POWDER-FORM FREEZE-DRIED COMPOSITION THAT HAS BEEN MADE INTO FINE PARTICLES
