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СТЕРИЛЬНЫЙ ИНЪЕЦИРУЕМЫЙ ВОДНЫЙ СОСТАВ НА ОСНОВЕ СШИТОЙ ГИАЛУРОНОВОЙ КИСЛОТЫ И ГИДРОКСИАПАТИТА ДЛЯ ТЕРАПЕВТИЧЕСКОГО ПРИМЕНЕНИЯ
专利权人:
АПТИССЕН С.А. (CH)
发明人:
ГАВАРД МОЛЛИАРД Сэмюэл (FR)
申请号:
RU2015109085
公开号:
RU2015109085A
申请日:
2013.09.24
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. A sterile aqueous injectable composition, sterilized with moist heat, used for therapeutic purposes, in the form of a cohesive, viscoelastic gel based on particles, containing: i) crosslinked hyaluronic acid or one of its salts in a concentration of from 1% to 4% (weight / volume) ; the crosslinking performed makes it possible to obtain a gel based on crosslinked hyaluronic acid having a so-called cohesive structure, and ii) hydroxyapatite in a concentration of from 10% to 70% (mass / volume), wherein said hydroxyapatite is present in the form of particles having an average size of less than or equal to from 80 μm to 500 nm; wherein said sterile injectable aqueous composition has viscoelastic properties in which Tanδ at a frequency of 1 Hz is less than or equal to 0.60 as determined by performing a frequency sweep from 0.01 d about 100 Hz using a rheometer with a plate geometry of 40 mm, a working air gap of 1000 micrometers and an analysis temperature of 25 ° C. 2. The sterile injectable aqueous composition according to claim 1, characterized in that the molecular weight of hyaluronic acid or one of its salts is from 2.5 × 10 Da to 4 × 10 Da. 3. A sterile injectable aqueous composition according to claim 1, characterized in that the concentration of crosslinked hyaluronic acid or one of its salts is from 1% to 3% (weight / volume). Sterile injectable aqueous composition according to paragraphs. 1-3, characterized in that the concentration of hydroxyapatite is from 20% to 60% (mass / volume), preferably from 30% to 50% .5. Sterile injectable aqueous composition according to paragraphs. 1-3, characterized in that the composition may further comprise one or more ceramic materials, such as tricalcium phosphate. 6. Sterile injectable aqueous composition according to claim 5, characterized in that the ceramic material1. Стерильный водный инъецируемый состав, стерилизованный влажным теплом, применяемый для терапевтических целей, в виде когезионного вязкоэластичного гел
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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