Rezac, Jaroslav,Pribyl, Daniel,Hanovska, Anna,Dammer, Ondrej
申请号：
HUE13002930
公开号：
HUE036989T2
申请日:
2013.06.06
申请国别(地区):
HU
年份:
2018
代理人:
摘要：
A pharmaceutical formulation of agomelatine for oral use, comprising - agomelatine in the form of agomelatine co-crystals with organic acids and - pharmaceutically acceptable excipients, in which - the agomelatine co-crystals are used in the form of pre-blend of the agomelatine co-crystals with a glidant, - the ratio of the agomelatine co-crystals to the glidant in the pre-blend is lower than or equal to 30 : 1, and - the free-water content in the used pharmaceutically acceptable excipients is lower than or equal to 7% w/w.
