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GLUCAGON/GLP-1 RECEPTOR CO-AGONISTS
专利权人:
发明人:
申请号:
HK11109129.2
公开号:
HK1154799A
申请日:
2011.08.30
申请国别(地区):
HK
年份:
2012
代理人:
摘要:
Modified glucagon peptides are disclosed having enhanced potency at the glucagon receptor relative to native glucagon. Further modification of the glucagon peptides by forming intramolecular bridges or the substitution of the terminal carboxylic acid with an amide group produces peptides exhibiting glucagon/GLP-1 receptor co-agonist activity. The solubility and stability of these high potency glucagon analogs can be further improved by modification of the polypeptides by pegylation, acylation, alkylation, substitution of carboxy terminal amino acids, C-terminal truncation, or the addition of a carboxy terminal peptide selected from the group consisting of SEQ ID NO: 26 (GPSSGAPPPS), SEQ ID NO: 27 (KRNRNNIA) and SEQ ID NO: 28 (KRNR).
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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