The present invention features methods, devices, and kits for detecting alevel of one or morebiomarkers in a patient having cancer or determining the responsiveness of apatient having cancer toa treatment, such as treatment with a secretory phospholipase A2 (sPLA2)hydrolysable, cisplatin-containingliposome. The invention further includes methods of treating a patient havingcancer byadministering, e.g., the liposome.