PROBLEM TO BE SOLVED: To provide a low-melting point medicine-containing granules free from oozing out of a low-melting point substance and aggregation of granules when stored at a high temperature and further free from tableting hinderance such as sticking even when preparing tablets by tableting and to provide a method for producing the low melting point medicine-containing granules in limited production of diversified products and in good productivity by using a general granulating machine and a fluid bed drying machine.SOLUTION: The low-melting point medicine-containing granules are obtained by granulating mixed powder containing a low melting point medicine having &ge30°C and &le80°C melting point and an adsorbing carrier and then fluidizing the resultant granules at an air supply temperature not lower than the melting point by using a fluidized bed drying machine.COPYRIGHT: (C)2006,JPO&NCIPI【課題】高温保存時に低融点物質の沁み出しや粉粒体の凝集が無く、更に打錠により錠剤を製してもスティッキング等の打錠障害が無い低融点薬物含有粉粒体を提供する。また、当該低融点薬物含有粉粒体を一般的な造粒機と流動層乾燥機を用いた、小量多品種で生産性の良い製造方法で提供する。【解決手段】融点が30℃以上かつ80℃以下である低融点薬物、及び吸着担体を含有する混合粉体を造粒することによって得られる造粒物を、流動層乾燥機を用いて融点以上の給気温度で流動することによって得られる、低融点薬物含有粉粒体。【選択図】なし
