Goldenhelm, Paul D.,Kaiko, Robert F.,Reder, Robert F.
申请号：
AU2008261134
公开号：
AU2008261134B2
申请日:
2008.12.19
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
#$%^&*AU2008261134B220120802.pdf#####Method of Providing Sustained Analgesia with Buprenorphine Abstract The use of buprenorphine in the preparation of a medicament for a method of effectively treating pain in humans is achieved by administering burenorphine in a 5 manner indicative of first order pharmacokinetics over an initial three-day dosing interval, such that a maximum plasma concentration from about 20 pg/ml to about 1052 pg/ml is attained, and thereafter maintaining the administration of buprenorphine for at least an additional two-day dosing interval in a manner indicative of zero order kinetics, such that the patients experience analgesia throughout the at least two-day additional dosing 10 interval (Figure 1).
