Allen, Shelley,Andrews, Steven W.,Blake, James F.,Condroski, Kevin R.,Haas, Julia,Huang, Lily,Jiang, Yutong,Kercher, Timothy,Kolakowski, Gabrielle R.,Seo, Jeongbeob,Jiang, Yuton
申请号：
HRP20161786
公开号：
HRP20161786T1
申请日:
2016.12.27
申请国别(地区):
HR
年份:
2017
代理人:
摘要：
Compounds of Formula I: or stereoisomers, tautomers, or pharmaceutically acceptable salts, or solvates or prodrugs thereof, where R1, R2, Ra, Rb, Rc, Rd, X, Y, B, and Ring C are as defined herein, and wherein the Y&mdash；B moiety and the NH&mdash；C(&boxH；X)&mdash；NH moiety are in the trans configuration, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases.
