System and methods for stimulating the neurovascular system of the cerebral tissue through optimally placed devices while simultaneously measuring the evoked neuronal and hemodynamic responses also using optimally placed devices is disclosed. Systems and methods for iteratively stimulating the neurovascular system and recording neuronal and hemodynamic responses are also disclosed. Further a method for determining cerebral neurovascular functioning from the combined stimulation and measurement is disclosed for use in diagnosis of neurovascular disorders.
