The protective effect on peritoneum of L－carnitine and its lower alkanoyl derivatives, both in the form of inner or pharmaceutically acceptable salts is disclosed. Concentrations of carnitine from about 0.02 to 0.5% w/v are suitable for preparing a solution for peritoneal dialysis having higher biocompatibility and protecting peritoneum from toxic effects of continuous use of solutions for peritoneal dialysis, in particular ones containing glucose as osmotic agent. A particularly preferred embodiment is a solution for peritoneal dialysis containing carnitine, glucose and xylitol.本發明揭示L－肉毒鹼及其低級烷醯衍生物(二者均為內鹽或藥學上可接受之鹽的型式)對腹膜之保護功效。適於製備具有較高之生物相容性並保護腹膜免於因持續使用腹膜透析溶液(尤其是含有葡萄糖作為滲透劑者)所造成之毒性效果的腹膜透析溶液之肉毒鹼濃度為約0.02至0.5重量/體積%。特別適宜之較佳體系為含有肉毒鹼、葡萄糖及木糖醇之腹膜透析溶液。
