Described is an autoinjector (1) comprising a spring holder (19), a guide cylinder (15) releasably coupled to the spring holder (19), a drive assembly (17) releasably coupled to the spring holder (19), a drive spring (16) adapted to apply a force on the drive assembly (17), and a penetration spring (20) adapted to apply a force on the guide cylinder (15). The guide cylinder (15) is adapted to accommodate a syringe (2) having a plunger. The drive assembly (17) is coupled to the guide cylinder (15) and adapted to engage the plunger.