The present invention provides a technique for continuous measurement of blood pressure based on pulse transit time and which does not require any external calibration. This technique, referred to herein as the "Composite Method", is carried out with a body- worn monitor that measures blood pressure and other vital signs, and wirelessly transmits them to a remote monitor. A network of body- worn sensors, typically placed on the patient"s right arm and chest, connect to the body- worn monitor and measure time- dependent ECG, PPG, accelerometer, and pressure waveforms. The disposable sensors can include a cuff that features an inflatable bladder coupled to a pressure sensor, three or more electrical sensors (e.g. electrodes), three or more accelerometer s, a temperature sensor, and an optical sensor (e.g., a light source and photodiode) attached to the patient"s thumb.
