Paul Workman;Peter Martin Fischer;Edward McDonald;Michael Jarman;Bernard Nutley;Florence Raynaud;Stuart Wilson
发明人:
Peter Martin Fischer,Michael Jarman,Edward McDonald,Bernard Nutley,Florence Raynaud,Stuart Wilson,Paul Workman
申请号：
US12489663
公开号：
US08846696B2
申请日:
2009.06.23
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention relates to compounds of formula 1or pharmaceutically acceptable salts thereof, whereinone of R1 and R2 is methyl, ethyl or isopropyl, and the other is H；R3 and R4 are each independently H, branched or unbranched C1-C6 alkyl, or aryl, andwherein at least one of R3 and R4 is other than H；R5 is a branched or unbranched C1-C5 alkyl group or a C1-C6 cycloalkyl group, each of which may be optionally substituted with one or more OH groups；R6, R7, R8 and R9 are each independently H, halogen, NO2, OH, OMe, CN, NH2, COOH, CONH2, or SO2NH2.A further aspect of the invention relates to pharmaceutical compositions comprising compounds of formula 1, and the use of said compounds in treating proliferative disorders, viral disorders, stroke, alopecia, CNS disorders, neurodegenerative disorders, or diabetes.
