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Methods for conjugation of oligosaccharides or polysaccharides to protein carriers through oxime linkages via 3-deoxy-D-manno-octulsonic acid
专利权人:
Joanna Kubler-Kielb
发明人:
Joanna Kubler-Kielb,Vince Pozsgay,Teresa Lagergard,Gil Ben-Menachem,Rachel Schneerson,Evguenii Vinogradov,Ariel Ginzberg
申请号:
US12309428
公开号:
US08795680B2
申请日:
2007.07.18
申请国别(地区):
US
年份:
2014
代理人:
摘要:
Methods for preparing an oligosaccharide-protein carrier immunogenic conjugate or a polysaccharide-protein carrier immunogenic conjugate. The methods include obtaining an oligosaccharide or polysaccharide having a KDO moiety located at the terminal reducing end of the oligosaccharide or polysaccharide that includes a carbonyl functional group and reacting the carbonyl functional group of the KDO moiety with an aminooxylated protein carrier molecule resulting in a conjugate that includes a covalent oxime bond between the oligosaccharide and the protein carrier or the polysaccharide and the protein carrier.
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